Category: Head & Neck Cancer

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Debio 1143-SCCHN-301
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Debio 1143-SCCHN-301

Randomized, double-blind placebo-controlled, Phase 3 study of Debio 1143 in combo with platinum-based chemo and standard fractionation IMRT in patients with locally advanced squamous cell carcinoma of the head and neck, suitable for definitive chemoradiotherapy (TrilynX). Squamous cell carcinoma of the head and neck (SCCHN) is the 6th most common cancer worldwide. More than half...

QUILT 3.055 Study – Multiple Solid Tumor Cancers
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QUILT 3.055 Study – Multiple Solid Tumor Cancers

QUILT-3.055: A Phase 2b, Single-Arm, Multicohort, Open-Label Study of Combination Immunotherapies in Patients Who Have Previously Received Treatment with PD-1/PD-L1 Immune Checkpoint Inhibitors.     DRUGS: N-803 (aka ALT-803) + PD-L1 t-haNK suspension for infusion This study is designed to treat multiple solid tumor cancers. This type of study is done because of how the...

Merck Study – Head and neck squamous cell carcinoma
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Merck Study – Head and neck squamous cell carcinoma

A Phase 2, randomized, open-label three-arm clinical study to evaluate the safety and efficacy of lenvatinib (E7080/MK-7902) in combination with pembrolizumab (MK-3475) versus standard of care chemotherapy and lenvatinib monotherapy in participants with recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC) that have progressed after platinum therapy and immunotherapy (PD-1/PD-L1 inhibitors) (LEAP-009) We are...

BASKET Study – Covers multiple solid tumor cancer types
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BASKET Study – Covers multiple solid tumor cancer types

An Open-label, Multicenter, Multicohort, Phase 2 Study to Evaluate Enfortumab Vedotin in Subjects with Previously Treated Locally Advanced or Metastatic Malignant Solid Tumors (EV-202) This study is designed to treat multiple solid tumor cancers. This type of study is done because of how the drug is expected to work against cancer. This study will enroll...