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Immunotherapy Drug Is Providing Exciting Results in the Treatment of Lung Cancers

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Alex was in his early 40s when he was diagnosed with Stage 4 Lung Cancer. A non-smoking, healthy man, who exercises regularly and eats relatively well is not who most people think of when they think of lung cancer.  However, people exactly like Alex are the new faces of lung cancer diagnoses. Alex is also one of a select few who qualified for a new targeted therapy drug recently approved by the FDA.

Lung cancer is the leading cause of cancer death globally, causing 1.7 million deaths a year. In the United States, it is expected to kill more than 154,000 people in 2018, but recent studies are producing credible progress in finding new drugs that, when combined with more traditional chemotherapy, are greatly improving the survival rates among lung cancer patients. The findings are dramatically changing the way physicians are treating lung cancers. “What it suggests is that chemotherapy alone is no longer a standard of care,” said Dr. Leena Gandhi, a leader of the study and director of the Thoracic Medical Oncology Program at the Perlmutter Cancer Center at New York University Langone Health.

So far, four drugs called checkpoint inhibitors, which unleash the patient’s own immune system to kill malignant cells, have been approved by the FDA. “I’ve been treating lung cancer for 25 years now, and I’ve never seen such a big paradigm shift as we’re seeing with immunotherapy,” said Dr. Roy Herbst, Chief of Medical Oncology at the Yale Cancer Center.

In the trial, patients with metastatic nonsquamous non-small cell lung cancer (NSCLC) who received the drug pembrolizumab (Keytruda) plus chemotherapy had improved overall survival and progression-free survival compared with just chemotherapy alone.  The results from the KEYNOTE-189 clinical trial were presented at the annual meeting of the American Association for Cancer Research (AACR) in Chicago on April 16 and published concurrently in the New England Journal of Medicine.

One of the main factors in the high rate of death due to lung cancer is that the disease is most often undetected until it has spread to other organs of the body. Lung cancer is the second most prevalent form of cancer in men and women and the top cancer killer among both sexes. In addition to the encouraging results from immunotherapy drugs, a newly discovered protein is showing promising results in detecting lung cancer earlier, providing new advanced treatment options to patients at the earliest stages of the disease. “The use of CKAP4 as a biomarker could change current practices regarding the treatment of lung cancer patients, and the diagnostic accuracies may be markedly improved by the combination of CKAP4 and conventional markers,” says Yuichi Sato, Division of Molecular Diagnostics, Kitasato University.

While the news of earlier discovery and new treatment options is very good, reducing risk factors for the disease remains the best approach to avoiding cancer. Exposure to tobacco smoke is one of the leading causes of lung cancer. Smoking marijuana and using electronic cigarettes may also increase the risk of lung cancer, but the actual risk is unknown. People who work with asbestos in a job such as shipbuilding, asbestos mining, insulation, or automotive brake repair and who smoke have a higher risk of developing cancer of the lungs. Exposure to radon has been associated with an increased risk of some types of cancer, including lung cancer. Having your home tested for the presence of Radon is a good and economical method for reducing the risk. Some people also have a genetic predisposition for lung cancer. People with parents, brothers, or sisters with lung cancer could have a higher risk of developing the cancer themselves.

Understanding cancer and how to treat it is constantly evolving toward the day when a cure is discovered. The cure is not here yet, but treatment options have greatly improved in recent decades. The treatments and methods used in clinical trials are promising in every environment in which they are tested. For more information on advancements in cancer detection and treatment, visit http://gettysburgcancercenter.com/.

The Importance of Taking Care of the Caregiver

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For cancer patients, receiving a diagnosis is often a time of fear, stress and trauma. The fear of the unknown, treatment processes and the disruption to life’s routines can be overwhelming. The experience is life altering, not only for the patient but also for family and close friends. For certain, life will never be the same for all involved.

While the initial focus and turmoil centers around the patient, the emotional impact on those who step up to be caregivers are too often overlooked. The dedication of time and resources to drive the patient to their frequent treatments, look in on them to monitor the therapies’ progress and extend their understanding and emotional support can be significant. Truly, no one fights cancer alone.

Being a caregiver can be very challenging. Many caregivers are close family and friends who are impacted equally by the diagnosis. The experience often creates a new role and unprecedented change for friend and family relationships. Feelings of confusion and stress accompany the changes in daily routines for all involved. Once relatively equal give and take relationships are now tipped more toward the cancer patient. Over an extended period of time this unbalanced set of emotional and physical needs can leave a caregiver feeling depressed and overwhelmed.

Educating yourself about the patient’s disease and the therapies and treatments they will be experiencing can help a caregiver cope with the challenges that lie ahead.  “I remember it was important for me to understand the kind of breast cancer my wife (Viola) had,” says Nathan Jones.  “It was triple-negative, so it was very aggressive. Because I had learned everything I could about Viola’s cancer, I understood that even though she wasn’t sick in bed or even in pain, her cancer was going to grow fast and we needed to be proactive.” Knowing and understanding is nearly always better and less stressful.

Many caregivers admit, usually in hindsight, that they took on too much. Accepting help from others and sharing feelings of being over taxed is never easy, but having someone assist with routine chores like cooking, cleaning, shopping and yardwork can relieve the pressure on a caregiver’s time, energy and feelings of inadequacy.  Focusing on your own needs, hopes, and desires can give you the strength to meet new challenges and understand conflicting feelings.

Support groups dedicated to caring for the caregiver are widely available in small group settings or online. Studies show that talking with others about what you’re dealing with is very important. It’s especially helpful when you feel overwhelmed or want to say things that you can’t say to your loved one with cancer.

Keeping a journal has been shown to help relieve negative feelings and stress. Share your journey with others who show interest.  Ken Owenson, caregiver and husband to a breast cancer patient says, “We find a lot of strength from sitting down with patients and giving them a place to vent some of their anxiety, and it also gives us a chance to clear our minds, too.  It’s not good to internalize it because that just makes it worse.”

For more information on how you can better manage your caregiver journey, contact the cancer care specialists at http://gettysburgcancercenter.com/contact-us/.

Cancer Mortality Rates Continue to Decline in The U.S.

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Continuing a positive trend for the last two decades, cancer death rates declined again last year. According to annual statistics reported from the American Cancer Society, the cancer death rate for men and women combined has fallen 26% from its peak in 1991. This decline translates to nearly 2.4 million deaths averted during this time period.

“Cancer Statistics, 2018,” was published in the American Cancer Society’s journal CA: A Cancer Journal for Clinicians. The information is also available in a companion report, Cancer Facts and Figures 2018, and on a website, the Cancer Statistics Center. Although cancer death rates continue to decline, a total of 1,735,350 new cancer cases and 609,640 deaths from cancer are projected to occur in the US in 2018.

The decline is mostly due to steady reductions in smoking and advances in early detection and treatment. “This new report reiterates where cancer control efforts have worked, particularly the impact of tobacco control,” said Otis W. Brawley, M.D., chief medical officer of the American Cancer Society. “A decline in consumption of cigarettes is credited with being the most important factor in the drop in cancer death rates. Strikingly though, tobacco remains by far the leading cause of cancer deaths today, responsible for nearly 3 in 10 cancer deaths.”

Lung, breast, prostate, and colorectal cancers are leading the way in lower death rates. Lung cancer death rates declined 45% from 1990 to 2015 among men and 19% from 2002 to 2015 among women. Early detection of breast cancer resulted in a 39 percent decline in death rates in women for the same period. Prostate and colorectal cancer experienced a 52 percent reduction between 1970 and 2015, primarily due to increased routine screening.

According to the report, the reduction in death rates is not equal across all ethnic, racial and social economic classes of population. The rates of new cancer occurrence are generally highest among African Americans and lowest for Asian Americans.

Cancer remains the second most common cause of death among children ages 1 to 14 in the U.S. Leukemia accounts for almost a third of all childhood cancers, followed by brain and other nervous system tumors. While child death rates due to cancer have continuously declined since 1975, cancer incidence rates increased in children and adolescents by 0.6% per year for the same period.

The report also reveals that the lifetime probability of being diagnosed with cancer is 39.7% for men and 37.6% for women. The most common cancers to be diagnosed in men are prostate, lung, and colorectal cancers. The most common cancers to be diagnosed in women are breast, lung, and colorectal cancers. Breast cancer accounts for 30% of all new cancer diagnoses in women. Liver cancer incidence continues to increase rapidly in women, but appears to be stabilizing in men.

The good news is particularly rewarding to the professionals at Gettysburg Cancer Center where their understanding of cancer and how to treat it is constantly evolving toward the day when they have a cure. Testing new procedures for identifying and diagnosing certain diseases and conditions, finding ways to prevent certain diseases or conditions before they have a chance to develop, and exploring new methods of supportive care for patients with chronic diseases are at the core of the ongoing clinical trials at the Center.

Early Detection and Treatment May Prevent Cervical Cancer

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Each year, an estimated 12,820 women in the United States will be diagnosed with some form of cervical cancer. Approximately 4,200 women die from the disease each year, and more than a quarter of a million women will live with the disease each year.  While the numbers can be daunting, when detected early, 91 percent of those diagnosed with cervical cancer will survive.

Long-lasting infections with certain types of human papillomavirus (HPV) cause almost all cases of cervical cancer. Normal cells of the cervix can gradually develop pre-cancerous changes.  These cells do not suddenly change into cancer. Instead, the normal cells of the cervix first gradually develop pre-cancerous changes that may turn into cancer.

The two main types of cervical cancer are squamous cell carcinoma and adenocarcinoma and represent the vast majority of cancer of the cervix. Only some of the women with pre-cancers of the cervix will develop cancer, and it may take several years for cervical pre-cancer to change to cervical cancer. For most women, pre-cancerous cells will go away without any treatment, but others will have their pre-cancers turn into invasive cancers.

Detecting and treating all cervical pre-cancers may prevent true cervical cancers. The Pap test (or Pap smear) and the HPV test may prevent cervical cancer by detecting pre-cancers before they can turn into an invasive form of cancer. During the past several decades, screening has reduced deaths from cervical cancer by finding the cancer early and treating it or preventing it from developing.

For women it can be very hard not to be exposed to HPV. Passed from one person to another during skin-to-skin contact with an infected area of the body, HPV can be spread rapidly and easily.

Available vaccines can protect against infection with the HPV subtypes most commonly linked to cancer. These vaccines help prevent pre-cancers and cancers of the cervix. The vaccines require a series of injections and may cause some mild side effects. The most common are is short-term redness, swelling, and soreness at the injection site.

The American Cancer Society recommends vaccinations for girls and boys beginning at age 11 or 12. HPV vaccination is also recommended for females 13 to 26 and males between the ages of 13 and 21. Vaccination at older ages is less effective in lowering cancer risk. No vaccine provides complete protection against all cancer-causing types of HPV, so routine cervical cancer screening is still recommended.

For more than 25 years, Gettysburg Cancer Center has been committed to providing cancer care in a community-based setting close to home. A leader in Oncology care across the region since 1989, Gettysburg Cancer Center’s cancer team provides screening and treatment options to women across York and Adams County.

For the latest information on early detection and treatments for cervical cancer, contact the Gettysburg Cancer Center.

The Value of a Community-Based Cancer Center

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The diagnosis of Cancer most often is accompanied by an intense emotional reaction, denial and a deep sense of dread and fear. The initial reaction is to seek the most information about the disease and the best treatment options available, no matter the cost of time and expense. The travel can impose a significant burden on cancer patients and their families already struggling with a significant life challenge.

In the historically famous but small community of Gettysburg, Pennsylvania, The Gettysburg Cancer Center (GCC) is meeting the challenges of providing expert comprehensive medical oncology, radiation, diagnostic and radiology services to their community in one location, eliminating the need to travel to regional centers.  With access to expert clinicians and staff, GCC is able to offer quality and comprehensive care in one location.

Adams Diagnostic Imaging (ADI) is an integral part of the GCC. An ACR Certified Imaging Center, ADI is a fully accredited facility focused on providing comprehensive diagnostic services. Whether it is MRI, PET-Scan, Stand Alone CT, Nuclear Medicine, Ultra sound or XRAY, the professional staff at ADI has the latest diagnostic tools available to serve their patient’s specific and individualized needs at affordable prices for the insured and those who self-pay. Their Physicians and highly trained technologists are certified through the ARRT with comprehensive experience and knowledge in radiology. The facility provides flexible scheduling to better accommodate patients by offering longer time slots to improve the patients’ recovery experience.

Clinical trials are an important part of the constantly evolving process of bringing new treatments to market to improve patient outcomes. At GCC, clinical trials are conducted after exhaustive research and development in the lab and are offered to patients to treat or prevent the recurrence of the disease. The first site in the United States to enroll a patient in a pivotal oral chemotherapy trial for all patients with advanced malignancies, GCC clinical trials are some of the most advanced in the field of cancer treatment. The clinical research department at Gettysburg Cancer Center is on the cutting edge of cancer clinical trials.

For more than 25 years, Gettysburg Cancer Center has been committed to providing cancer care in a community-based setting, close to home. The Center works with Hershey Medical Center’s Surgical Oncology Department for all solid tumor board conferences and also collaborates with John Hopkins University and NHI for complicated patient diagnoses.

The Gettysburg Cancer Center prides itself on providing individualized treatment, utilizing the best technical approach, and recognizing each individual patient’s psychological, emotional, and spiritual needs during their journey with their illness and healing.

For more information about Gettysburg Cancer Center, visit www.gettysburgcancercenter.com.

Finding New Solutions in the Fight Against Cancer Through Research

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While the most overt cancer research news usually comes from efforts to derail the progression of the deadly disease, research into the development of alternative pathways to finding an ultimate solution to cancer often go unnoticed or fail to receive the same level of notice among the public. Advances are being made in new techniques to improve the effectiveness of traditional treatment protocols, the utilization of non-traditional or culturally specific treatment methods or identifying dietary or physical behaviors that may lead to increasing or decreasing the risk factors associated with cancer.

An innovative new treatment for an aggressive form of blood cancer has been approved by the U.S. Food and Drug Administration. According to Mounzer Agha, Director of the Mario Lemiuex Center for Blood Cancers at Hillman Cancer Center, the cell based therapy produced a 51 percent remission rate among patients with a strain of lymphoma that didn’t respond well to traditional chemotherapy or radiation. “There was no treatment that could possibly put them into remission, so to get a 50 percent remission rate with this kind of treatment is a major accomplishment,” Agha said. This is a breakthrough for patients and physicians, according to Agha. The treatment is customized to each individual’s immune system. “This type of therapy represents a paradigm shift in the treatment of blood cancer and it will completely change the landscape of how we approach and treat blood cancers in the future,” he said.

In oriental medicine, treatment using acupuncture needles has been commonly practiced for thousands of years in the fields of treating musculoskeletal disorders, pain relief, and addiction relief. Recently, it has emerged as a promising treatment for brain diseases, gastrointestinal disorders, nausea, and vomiting, and studies are under way to use acupuncture to treat severe diseases. A research team lead by Professor Su-Il In, through joint research with Dr. Eunjoo Kim of Companion Diagnostics & Medical Technology Research Group at DGIST and Professor Bong-Hyo Lee’s research team from the College of Oriental Medicine at Daegu Haany University, has published a study showing that the molecular biologic indicators related to anticancer effects are changed only by the treatment of acupuncture. The research was published in the online edition of Scientific Reports, the sister journal of the globally renowned academic journal Nature. Professor Su-Il In said, “This research, which combines nanotechnology and oriental medicine technology, is a scientific study that shows the possibility of using acupuncture as a method to treat severe diseases such as cancer.”

For decades researchers have known that dietary issues can often be a factor in the incidence of cancer. In a paper published in the journal Nature Communications, researchers from VIB, a life sciences research institute, and Vrije University in Brussels found that a compound in sugar stimulates aggressive cancer cells and helps them to grow faster. Led by Johan Thevelein, a microbiologist with VIB, this research builds on what scientists already knew about the Warburg effect, where cancer cells rapidly break down sugar for energy and to fuel for further growth. While the research identifies a link between sugar and the aggressiveness of cancer cells, it doesn’t mean that eliminating sugar from one’s diet will eliminate the likelihood of getting cancer. “We have no evidence of this effect happens in healthy people,” Thevelein says, but “Reducing sugar intake during cancer treatment might help the system to overcome the cancer and it might facilitate the action of chemotherapy because it’s difficult to kill the cancer cells if they’re always activated [by sugar],” he says. “Providing sugar to cancer cells carries a greater risk of stimulating their aggressiveness.”

In Queensland, Australia scientist Georgia Chenevix-Trench has uncovered an additional 72 genetic markers that can indicate an increased likelihood that a patient may be more susceptible to getting cancer in their lifetime.  The discovery may lead to the development of a more definitive predictive test for breast cancer in women.

While most of us hope for quick and all-encompassing cure for cancer, the complexity and the infinite variety of cancer types indicate that a single solution is more than unlikely. The ultimate solutions will come from a combination a multitude of treatments and advances in early prediction and detection.

Gettysburg Cancer Center is actively involved with a consortium of doctors offering clinical trials for patients seeking alternative solutions and therapies.  For more information on the current clinical trials available, visit http://gettysburgcancercenter.com/patients/clinical-trials/.

Gene Therapy. A New Frontier in Medical Innovation

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Cancer is a disease that is experienced by young and old and by every economic and social segment of the world populace. At some point in everyone’s life, cancer will affect us individually, a member of our family or one or many of our friends and acquaintances. The American Cancer Society projects there will be 1,688,780 new cancer patients and 600,920 deaths due to cancer in 2017, for a disease that does not discriminate by race or national origin.

Cancer is where abnormal cell growths form in the body and interfere with normal, healthy body functions. Not new to the world stage, cancer dates back to ancient times. Today, after millennials of research and discovery, new treatments for a vast array of cancer types are being studied, many with promising results.  One such new treatment called chimeric antigen receptor T-cell therapy (CAR-T) involves taking samples of T-immune cells called T-cells from a patient, genetically engineering them, and putting them back in to fight the cancer. Co-developed with the drug giant Novartis, the therapy, CAR-T, genetically alters a patient’s own immune cells to target and destroy cancer cells.

“We’re entering a new frontier in medical innovation with the ability to reprogram a patient’s own cells to attack a deadly cancer,” said FDA Commissioner Dr. Scott Gottlieb. The process takes about 22 days and begins with the extraction of a patients T cells, exposing them to the vector which genetically transforms them. They’re then expanded and frozen for shipment back to the patient. During the out-of-body processing of the cells, the patient receives chemotherapy to wipe out any remaining T cells to avoid interference with the, soon to be, newly implanted cells.

“This is a major advance, and is ushering in a new era,” said Malcolm Smith, a pediatric oncologist at the National Institutes of Health. The treatment appears to strengthen a patient’s immune system allowing their own body to fight the cancer. The treatment is recommended for cancer patients who have run out of options for traditional therapy. The new therapy is only currently available for patients 25 years or younger. Thus far, 83 percent of patients are experiencing positive survival results.

While overtly touting the success of gene therapy, researchers are tempering their enthusiasm after experiencing some significant life threatening side effects in 47 percent of the studies participants. These side effects have resulted in brain swelling and deaths, casting a shadow over the field. Seizures and hallucinations were also relatively common, but temporary. Though concerning, the side effects have been successfully managed with drugs. Quality control and how to standardize the potency and purity of living cells extracted from each patient are also a concern. Because of the risks, the treatment is only currently available at 20 US hospitals. The individualized nature and relatively small patient population both drive up the cost of the treatment for now.

“This is a big paradigm shift, using this living drug,” says Dr. Kevin Curran, a pediatric oncologist at Memorial Sloan Kettering Cancer Center that will soon be offering the treatment. “It will provide a lot of hope. This is the beginning.”

“The approval of CAR T-cell therapy for pediatric leukemia marks an important shift in the blood cancer treatment paradigm,” says the American Society of Hematology. “We now have proof that it is possible to eradicate cancer by harnessing the power of a patient’s own immune system. This is a potentially curative therapy in patients whose leukemia is unresponsive to other treatments and represents the latest milestone in the shift away from chemotherapy toward precision medicine. Today’s approval is the result of over a decade of hematology research, including research funded by the National Institutions of Health (NIH).”

The Best in Cancer Care Across the Community

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Healthcare and access to quality healthcare is a critical issue for individuals whether healthy or recently diagnosed with a life-threatening illness.  Most patients have experienced a private medical practice being merged into a large healthcare system and often don’t understand how that will impact their care.

While large specialized health centers can promise to offer the most advanced techniques, facilities and methods, they are usually located in large urban centers, often miles and driving hours from the patient’s home, requiring long and physically taxing commutes for frequent treatments. Although staffed with caring and competent professionals these mega centers can often feel overly clinical and crowded, giving the patient a sense of being just another number among many.

The best and most advanced treatment and care is becoming less centralized, allowing for advanced specialized care to be available within the patient’s own community, providing ease of care access and reducing the personal stresses often accompanying cancer therapy.

Gettysburg Cancer Center (GCC) has been a leader in Oncology Care in the Adams County region since 1989. For more than 25 years, the highly regarded and vastly experienced medical specialists have been committed to providing cancer care in a community-based setting close to their patient’s home. The all-encompassing oncology and hematology programs provide a complete range of diagnosis, treatment, and follow-up care in an environment that recognizes the importance of treating not only the disease but the individual person behind the disease.

With Medical Oncology, Radiation Oncology, Diagnostic Imaging, access to the latest clinical trials as well as an onsite laboratory and pharmacy, Gettysburg Cancer Center truly offers comprehensive cancer care. Their compassionate and experienced staff takes pride in providing the best possible care and personal assistance to their patients and their patient’s families. Dr. Satish Shah, Principle Medical Oncologist and Hematologist at GCC says, “Our mission is to provide individualized treatment, utilizing the best technical approach.  We focus on providing the best treatment in the right environment so that our patients can focus on getting better.”

To learn more about how GCC’s is helping their cancer patients, click on http://gettysburgcancercenter.com/about-us/testimonials/.

October is Breast Cancer Awareness Month Around the World

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Billed as the most common cancer in women, breast cancer is impacting the lives of one in eight women in the United States. The second leading cause of cancer death in women after lung cancer, breast cancer most commonly occurs in women 50 years of age and older. Breast cancer is caused by a genetic mutation in the DNA of breast cancer cells but how or why this damage occurs isn’t fully understood. Some mutations may develop randomly over time, while others are inherited or may be the result of environmental exposures or lifestyle factors. More than 3.5 million women are living in the U.S. with a history of breast cancer.

Early detection remains the most important factor in the successful treatment and survivability of breast cancer. Caught early when known treatments have the best chance of success, breast cancer is survivable. Successful treatments include surgery, chemotherapy, radiation and immunotherapy. “Risk factors include being female, obesity, a lack of physical exercise, drinking alcohol, hormone replacement therapy during menopause, ionizing radiation, early age at first menstruation, having children late or not at all, older age, and family history.” With the clear lack of knowledge for its causes, early detection of the disease remains the cornerstone of breast cancer control.

National Breast Cancer Awareness Month (NBCAM) was founded in 1985 by the American cancer Society and what is now known as AstraZeneca Pharmaceuticals. Held each October, the event is an attempt to increase the awareness of breast cancer and to aid the solicitation of funds for research and treatment of the disease. NBCAM unites cancer organizations around the world in providing information and support for those suffering from the cancer. Breast Cancer Awareness is represented by the display of pink ribbons, first introduced by the Susan G. Komen Foundation at its New York City race for breast cancer survivors in 1991.

The effort by so many to bring worldwide attention to the disease appears to be having a positive impact. A new report from the American Cancer Society finds that death rates from breast cancer in the United States have dropped 39% between 1989 and 2015. The overall declines in breast cancer death rates have been attributed to both improvements in treatment and early detection by mammograms. The American Cancer Society recommends women find breast cancer earlier when treatments are more likely to be effective. While there is a lack or definite agreement on when and how often screening is most effective, The National Comprehensive Cancer Network recommends annual screening beginning at age 40.

The professional team of oncologists and staff at Gettysburg Cancer Center supports the efforts of Breast Cancer Awareness Month in its world-wide goal to provide the latest information, research, treatment options and support for those who suffer from breast cancer.

Cancer Research: Not Always an Exact Science

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It is the question most frequently asked of doctors by patients who have just received a diagnosis of cancer, “Why me?” It is usually asked by those who thought they were living a healthy lifestyle and had little expectation of receiving the devastating news. Others may have been aware of near or distant family members who had a form of cancer.

While much progress has been made in the effort to understand multiple forms of cancer and the development of effective treatments, the answer to why some people get the disease and others do not remains predominately an elusive mystery. Cancer is known to be caused by changes, or mutations, to the DNA within cells that can cause the cell to stop its normal function and may allow a cell to become cancerous. Some faulty genes that increase the risk of cancer, known as inherited cancer genes, and genes that increase the risk of cancer called cancer susceptibility genes can be passed on from parent to child. But most of genetic mutations appear to occur after birth and aren’t inherited.

Environmental influences such as smoking, radiation, viruses, persistent exposure to cancer-causing chemicals (carcinogens), obesity, hormones, chronic inflammation and a lack of exercise has been proven to provide a more definitive answer to the “Why Me?”. Even with this accepted knowledge, some people who share one or more of these environment factors appear to avoid a cancer diagnosis altogether.

Why do some cancers spread and kill patients, while many remain docile?  Seeking the answer to this question has researchers redirecting their approach for answers from why some get cancer to why so many do not. Ruslan Medzhitov, an Immunobiologist at Yale, says “You can inject the same virus into different hosts and get vastly different responses.”

Diagnosis and treatment becomes art and science. Researchers continue to develop and identify predictive tests based on gene mutations and patterns of gene regulation.  These tests assist in targeting the right therapies and treatments for each patient.  Research related to the micro-environments in which the cancer lives and spreads will provide beneficial to the prevention and early detection of cancer.

The field of oncology remains focused on a holistic approach factoring in the environment, genetic factors, and physiology, in the hopes of finding a concrete, science based answer to the “Why Me?”

To learn more about the clinical trials and research that Gettysburg Cancer Center offers its patients, click here.